Hodges EGC, Milner AD, Stokes GM,
Assessment of a new device for delivering aerosol drugs to asthmatic children.
Arch Dis Child 1981; 56:787-800.
Toogood JH, Jennings B, Baskerville J,
Lefcoe N, Newhouse M. Assessment of a device for reducing oropharyngeal
complications during beclomethasone aerosol treatment of asthma. Am Rev Respir
Dis 1981; 123(Suppl):113.
Corr D, Dolovich M, McCormack D, Ruffin R,
Obminski G, Newhouse M. Design and characteristics of a portable breath
actuated, particle size selective medical aerosol inhaler. J Aerosol Sci 1982;
13:1-7.
Gurwitz G, Levison H, Mindorf C, Reilly P,
Worsley G. Assessment of a new device (Aerochamber) for use with aerosol drugs
in asthmatic children. Annals of Allergy 1983; 50:166-170.
Dolovich M, Ruffin R, Corr D, Newhouse M.
Clinical evaluation of a simple demand inhalation MDI aerosol delivery device.
Chest 1983;84:36-41.
Clinical Evaluation of a simple Demand
Inhalation MDI Aerosol Delivery Device ~ Chest 1983;84:p36-41
Lawford P, McKenzie D, Alston D. The
effect of an aerochamber on bronchodilator response to a metered-dose inhaler.
Practitioner 1982;226: 2093-2095.
Berenberg MJ, Baigelman W, Cupples LA,
Pearce L. Comparison of metered-dose inhaler to an aerochamber with updraft
nebulizer for the administration of metaproterenol in hospitalized patients. J
Asthma 1985; 22:87-92.
Barbera JM, Sly RM, Eby DM, Middleton HB.
Responses to a bronchodilator aerosol delivered by Aerochamber to young
children. Annals of Allergy 1984;52:224.
Newman SP, Moren F, Pavia D, Clarke SW.
Deposition studies with spacer devices. In: Metered Dose Inhalers, Epstein SW,
ed. Astra Pharmaceuticals Canada Ltd., Mississauga. 1984;107-117.
Fractional Deposition From A Jet Nebulizer
How It Differs From AMetered Dose Inhaler~Br J Dis Chest 1985;79.63p361-367
〉程よ
Comparison of Metered-Dose Inhaler
Attached to an Aerochamber with an Updraft Nebulizer for the Administration of
Metaproterenol in Hospitalized Patients Journal of Asthma-1985;22(2)p87-90
Katz R, Rachelefsky G, Rohr A, Wo J,
Gracey V, Spector S, Siegel S. Use of tube spacer, Aerochamber(A), to improve
the efficacy of a metered dose inhaler (MDI) in asthmatic shildren. J Allergy
Clin Immunol 1986;77:185.
Fuller H. Comparison of two chamber
devices in patients using a metered-dose inhaler with satisfactory technique.
CMAJ 1986;135:625-629.
A Comparison of Two Delivery Methods for
Aerosolized Metaproterenol Sulfate~Joumal of Asthma -1986 ; 23(6) : p297-301
MEDICAL INTELLIGENCE CURRENT CONCEPTS
CONTROL OF ASTHMA BY AEROSOLS~THE NEW ENGLAND jOURNAL OF mEDICINE -1986p870-873
Rachelefsky GS, Rohr AS, Wo J, Gracey V,
Spector SL, Siegel SC, Katz RM, Mickey MR. Use of a tube spacer to improve the
efficacy of a metered-dose inhaler in asthmatic children. AJDC
1986;140:1191-1193.
Head CA, Rogers S, Christopher LE, McNeill
CG, George BF, Plummer AL. Comparison of metered dose inhaler with Aerochamber
(MDI) and hand held nebulizer (HHN) bronchodilator therapy in hospitalized
patients. Am Rev Respir Dis 1987;135:A226.
Fairshter RD. Evaluation of a metered-dose
aerosol delivery system using partial flow-volume curves. Am Rev Respir Dis
1987;135:741-743.
Special report cost-benefit comparison of
Aerosol Bronchodilator Delivery Methods in Hospitalized patients~Chest
1987;94(4):p614-618.
Crimi N, Palermo F, Cacopardo B, Vancheri
C, Oliveri R, Palermo B, Mistretta A. Bronchodilator effec of Aerochamber and
Inspirease in comparison with metered dose inhaler. Eur J Respir Dis
1987;71:153-157.
〉程よ
Salzman GA, Pyszczynski DR. Oropharyngeal
candidiasis in patients treated with beclomethasone dipropionate delivered by
metered-dose inhaler alone and with Aerochamber. J Allergy Clin Immunol
1988;81:424-8.
Equivalence of Continuous Flow Nebulizer
and Metered-Dose Inhaler with Reservoir Bag for Treatment of Acute Airflow
Obstruction~Chest -1988;p476-481
Lee H, Evans HE. Evaluation of inhalation
aids of metered dose inhalers in asthmatic children. Chest 1987;91:366-369.
Sly RM, Barbera JM, Middleton HB, Eby DM.
Delivery of albuterol aerosol by Aerochamber to young children. Annals of
Allergy 1988;60:403-406.
Gary A. Salzman. MD. and Dennis R.
Pyszczynski. MD. FCCP Oropharyngeal candidiasis in patients treated with
Beclomethasone dipropionate delivered by metered-dose inhaler alone and with
Aerochamber~J Allergy Clin Immunol -J ALLERGY CLIN IMMUNOL 1988;81:p424-428
Rothe VT, Mansfeld H-J, Schmitz-Schumann
M. Dosieraerosole in der Behandlung des kindlichen Asthma bronchiale. der
Kinderarzt 1988;19:679-683.
Konig P, Gayer D, Kantak A, Kreutz C,
Douglass B, Hordvik NL. A trial of metaproterenol by metered-dose inhaler and
two spacers in preschool asthmatics. Pediatr Pulmonol 1988;5:247-51.
Aerosol Bronchodilator Delivery
Methods~Arch Intern Med -1989
Aerosolized Metaproterenol in the
Treatment of Asthmatics with Severe Airflow Obstruction~Chest 1989;95:p1017-1020
Dexamethasone therapy for chronic lung
disease in ventilator-and oxygen-dependent infants Acontrolled
frial~JPediatr-1989;115:p979-983
Conner WT, Dolovich MB, Frame RA, Newhouse
MT. Reliable salbutamol administration in 6- to 36-month-old children by means
of a metered dose inhaler and aerochamber with mask. Pediatr Pulmonol
1989;6:263-267.
〉程よ
Clark AR, Rachelefsky G, Mason PL,
Goldenhersh MJ, Hollingworth A. The use of reservoir devices for the
simultaneous delivery of two metered-dose aerosols. J Allergy Clin Immunol
1990;85:75-9.
Aerosol therapy in the newborn~Archives of
Disease in Childhood-1990; p906-908
Metered Dose Inhaler Aerosol
Characteristics Are Affected by the Endotracheal Tube Actuator Adapter
Used~Anesthesiology -1990;73:p1263-1265
Benton G, Thomas RC, Nickerson BG,
McQuitty JC, Okikawa J. Experience with a metered-dose inhaler with a spacer in
the pediatric emergency department. Amer J Dis Child 1989;143:678-81.
Lee N, Rachelefsky G, Kobayashi RH,
Kobyashi AL, Siegel SC, Katz RM, Spector SL, Rohr AS. Comparison of efficacy and
safety of albuterol administered by power-driven nebulizer (PND) versus metered
dose inhaler (MDI) with Aerochamber and mask young children with acute asthma. J
Allergy Clin Immunol 1991;87:307.
Fuller HD, Dolovich MB, Posmituck G, Wong
Pack W, Newhouse MT. Pressurized aerosol versus jet aerosol delivery to
mechanically ventilated patients: Comparison of dose to the lungs. Am Rev Respir
Dis 1990;141:440-444.
Salzman GA, Steele MT, Pribble JP,
Elenbaas RM, Pyszczynski DR. Aerosolized metaproterenol in the treatment of
asthmatics with severe airflow obstruction: Comparison of two delivery methods.
Chest 1989;95:1017-20.
Aerosol Generators and Delivery
Systems~Respiratory Care 1991VOL36 NO 9 p939-951
Tesarowski DB, Viel L, Newhouse M, O'Byrne
PM, McDonell WN. Equine Heaves as a model for asthma in man. Am Rev Respir Dis
1991;143:A416.
How Should Bronchodilators Be Administered
to Patients on Ventilators~Respiratory Care 1991;p377-394
〉程よ
Metered Dose Inhalers for Bronchodilator
Delivery in Intubated Mechanically Ventilated Patients~Chest 1991;99:p66-71
Effects of Albuterol inhalation on the
Work of Breathing during Weaning from Mechanical Ventiltion~Am Rev Respir Dis
1991;144:p95-105
Newhouse MT. MDI plus aerochamber: aerosol
dosing for controlling reversible airflow obstruction and managing acute
exacerbations. Breathing Space 1990;1(3):10-13.
Colacone A, Afilalo M, Wolkove N, Kreisman
H. A comparison of Albuterol administered by metered dose inhaler (and holding
chamber) or wet nebulizer in acute asthma*. Chest 1993;104(3):835-841.
Tenholder MF, Bryson MJ, Whitlock WL. A
model for conversion from small volume nebulizer to metered dose inhaler aerosol
therapy. Chest 1992;101:634-37.
clinical investigations Substitution of
Metered-dose Inhalers For Hand-Held Nebulizers~Chest p305-308 -19922る
Bishop MJ, Larson RP, Buschmann DL.
Metered dose inhaler aerosol characertistics are affected by the endotracheal
tube actuator/adapter used. Anaesthesiology 1990;73:1263-65.
Grigg J, Arnon S, Jones T, Clarke A,
Silverman M. Delivery of therapeutic aerosols to intubated babies. Arch Dis
Child 1992;67:25-30.
A Model for Conversion from Small Vohaler
Aerosol Therapy~Chest p634-637 -19923る
Everard ML, Clark AR, Milner AD. Drug
delivery from holding chambers with attached facemask. Arch Dis Child
1992;67:580-85.
An Evaluation of MDI Spacers and Adapters
Their Effect on the Respirable Volume of Medication~Respiratory Care
1992;37:p862-868
〉程よ
Evaluation of a Reservoir Device for
Metered-Dose Bronchodilator Delivery to Intubated Adults~CHEST
-1992;102:p924-930
Rau JL, Harwood RJ, Groff JL. Evaluation
of a reservoir device for metered-dose bronchodilator delivery to intubated
adults. Chest 1992;102:924-30.
Bouchikhi A, Becquemin MH, Roy M,
Bertholon JR, Corallo F, Richard E. Etude de la gradulometrie et de la
concentration d'un medicament aerosolise (flunisolide). Presented at Congress de
Pneumologie de Langue Francaise, Montreal 1991.
Campbell R, Dolovich M, Chambers C,
Newhouse M. Holding chamber volume/salbutamol dose delivered through an
endotracheal tube at low tidal volumes. J Aerosol Med 1992;5:304.
Dolovich M, Chambers C, Mazza M, Newhouse
MT. Relative efficiency of four metered dose inhaler (MDI) holding chambers (HC)
compared to albuterol MDI. J Aerosol Med 1992;5:307.
Delivery of Micronized Budesonide
Suspension by Metered Dose Inhaler and Jet Nebulizer Into a Neonatal Ventilator
Circuit~Pediatr Pulmonol -1992;13:p172-175
Delivery of therapeutic aerosols to
intubated babies~Archives of Disease in Childhood -1992;67:p25-30
Niggemann B. Substitution of metered-dose
inhalers for hand-held nebulizers. Chest 1993;103:327.
Hofford JM. The metered-dose inhaler
supersedes the jet nebulizer. Chest 1993;103:327.
Reversibility of exogenous
corticosteroid-induced bone loss~Eur Respir -1993,6,p116-119
〉程よ
Self TH, Kelso TM, Arheart KL., Morgan JH,
Meduri GU. Nurses' performance of inhalation technique with metered-dose inhaler
plus spacer device. Ann Pharmacother 1993;27:185-7.
Nelson HS, Loffert DT. Comparson of the
bronchodilator response to metered dose inhaler (MDI) alone or with the
Aerochamber (AC) or Optihaler (OP). J Allergy Clin Immunol 1993;91:167.
Wolff AH, Oppenheimer J, Bielory L.
Comparison of metered dose inhaler (MDI) spacer devices. J Allergy Clin Immunol
1993;91:167
Timothy H. Self,Tiffany M. Kelso,
Kristopher L. Arheart. Joyce H. Morgan, and G. Umberto Meduri, Nurses
Performance of Inhalation Technique With Metered-dose Inhaler Plus Spacer
Device~The Annals of Pharmacotherapy Ann Pharmacother-1993;27:p185-187
Dosing Efficency and Particle-size
Charactristics of Pressurized Metered-dose Inhaler Aerosols in Narrow
Catheters~CHEST -1993;103:p920-924
Emergency Department Treatment of Severe
Asthma~CHEST -1993;103:p665-672
Gervais A, Begin P. Bronchodilatation with
a metered dose inhaler plus an extension, using tidal breathing vs jet
nebulization*. Chest 1987;92(5):822-824.
Fink J, Chand R, Jenne JW, Tobin MJ.
Effect of simulated patient effort on aerosol deposition during mechanical
ventilation: a laboratory bench study. Am Rev Respir Dis 1994;149:A74.
Coleman DM, Kelly HW, McWilliams BC,
Murphy S. The delivery of aerosolized albuterol through an infant ventilator
circuit: comparison of nebulizer and MDI with four spacers. Am Rev Respir Dis
1994;149:A1038.
Huang J-L, Hung I-J, Hsieh K-H. Effect of
inhaled beclomethasone dipropionate in the treatment of recurrent wheezing in
infancy and early childhood. J Formos Med Assoc 1993;92:1066-1069.
〉程よ
A Comparison of Albuterol Administered by
Metered Dose Inhaler (and Holding Chamber )or Wet Nebulizer in Acute
Asthma~Chest -1993;104:p835-841
Perry BJ, Langenback EG, Ilowite JS.
Optimizing aerosol therapy with a new automatic metered dose inhaler/spacer
combination. Am J Respir Crit Care Med 1994;149:A217.
Cunningham SJ, Crain EF. Reduction of
morbidity in asthmatic children given a spacer device. Chest 1994;106:753-57.
Campbell SC, Vagedes RT, Yaeger ES.
Efficacy of actuator devices in delivery of bronchodilators to mechanically
ventilated dogs. Chest 1994;106(Suppl):109S.
Sandra J. Cunningham, M. D., Ph.D.
Reduction of Morbidity in Asthmatic Children Given a Spacer Device~Chest -Cheat
1994;106:p753-757
Perry RJ, Langenback EG, Ilowite JS.
Clinical comparison of two aerosol holding chambers: ACE vs Aerochamber. Respir
Care 1994;39:1047-1050.
Chipps BE, Naumann PF, Wong GA, Raabe OG.
Clinical comparison of gentle-haler actuator and aerochamber spacer for metered
dose inhaler (MDI) use by asthmatics. Respir Care 1992;37:1414-1422.
Facemasks Versus Mouthpieces for Aerosol
Treatment of Asthmatic Children -Pediatr Pulmonol-1992;14:p192-196
Clarke FE, Montgomery LL, Stubbing D.
Randomized comparison of two spacer devices in subjects with reversible airflow
limitation. Can Respir J 1994;1:257-60.
〉程よ
Morris JF, Duncan, CR, Marr ML. Comparison
of two techniques for using bronchodilator MDIs plus spacer in COPD. Am J Respir
Crit Care Med 1994;149:A310.
Henninger D, Tarazewski R, Evans R, Frey
C, Albertini R. Comparison of four devices for delivering inhaled bronchodilator
in patients with chronic obstructive lung disease (COPD): Patient preference and
correlation with spirometry. Am J Respir Crit Care Med 1994;149:A310.
Chua HL, Chambers CB, Newhouse MT.
Comparison of the effect of four MDI add-on devices on lung deposition and
function in asthmatics. Am Rev Respir Dis 1994;149:A217.
Dolovich M, Chua HL, Chambers C, lerman J,
Newhouse M. A comparison of 8 methods for delivering aerosol to intubated
animals. Am J Respir Crit Care Med 1994;149:A1038.
Fok TF, Dolovich MB, Newhouse MT, Gray S,
Coates G, Monckman S, Paes B, Kirpilani H. Comparison of metered dose inhaler
(MDI) and jet nebulizer (JN) in delivery salbutamol (SALB) aerosol to infants
with bronchopulmonary dysplasia (BPD). Am J Respir Crit Care Med 1994;149:A546.
Bronchodilator aerosol administered by
metered dose inhaler and spacer in subacute neonatal respiratory distress
syndrome~Archivcs of Disease in Childhood -1994;70:pF218-F222
Teper AM, Kofman CD, Maffey AF, Vidaurreta
SM, Macri CN, Bergada' I, Heinrich JJ. Effect of inhaled beclomethasone
dipropionate (BDP) on pulmonary function, bronchial reactivity and longitudinal
growth in infants with bronchial asthma. Am J Respir Crit Care Med
1995;151:A150.
Treatment of Bronchospasm by Metered-Dose
Inhaler Albuterol in Mechanically Ventilated Patients~Chest 1995;107:p210-213.
Bronchodilator Delivery by Metered-dose
Inhaler in Ventilator-supported Patients~Am Respir Crit Care Med p1827-1833
-1995;151:p1827-1833
Lin Yung-Zen, Hsieh Kue-Hsiung. Metered
dose inhaler and nebuliser in acute asthma. Arch Dis Child 1995;72:214-218.
〉程よ
Parkin PC, Saunders NR, Diamond SA,
Winders PM, Macarthur C. Randomised trial spacer v nebuliser for actue asthma.
Arch Dis Child 1995;72:239-240.
Chou KJ, Cunningham SJ, Crain EF.
Metered-dose inhalers with spacers vs nebulizers for pediatric asthma. Arch
Pediatr Adolesc Med 1995;149:201-5.
Bisgaard H, Anhoj J, Klug B, Berg E.
Non-electrostatic-spacer (NES spacer) for aerosol delivery to young children: a
comparative study with Nebuhaler, AeroChamber and Babyhaler. J Aerosl Med
1995;8:88(Abstract P97).
Ashurst IC, Ambrose CV, Russell DJ.
Pharmaceutical evaluation of a new spacer device for delivery of metered-dose
inhaler to infants and young children. J Aerosol Sci 1992;23:S499-S502.
Manthous CA, Chatila W, Schmidt GA, Hall
JB. Treatment of bronchospasm by metered-dose inhaler albuterol in mechanically
ventilated patients. Chest 1995;107:210-13.
Mitchell J, Nagel M. Comparison of child
Aerochamber and Nebuhaler with Budesonide. 10th Biennial Congress, International
Society for Aerosols in Medicine. Hamilton, Ontario May 15-19.1995.
AARC Clinical Practice Guideline Selection
of an Aerosol Device for Neonatal and Pediatric Patients~Respir Care1995;40(12
Wu RS-C, Wu KC, Tsai YH, Cheng RK-S, Tan
PPC. inhaled fenoterol pretreatment attenuates airway resistance response to
endotracheal intubation. Acta Anaesthesiol 1995;33:7-14.
Grossman J, Tinkelman DG, Ziment I. Two
period multi-dose crossover comparison trial of pirbuterol administered via the
Maxair? Autohaler ? with VentolinR via AerochamberR (a spacing device).
Abstract-Asthma '95: Theory to Treatment, July 15-17, 1995; Chicago, IL.
Dhand R, Jubran A, Tobin MJ.
Bronchodilator delivery by metered-dose inhaler in ventilator-supported
patients. Amer J Respir Crit Care Med 1995;151:1827-1833.
Fok TF, Al-Essa M, Monkman S, Dolovich M,
Firard L, Coates G, Kirpalani H. Delivery of metered dose inhaler aerosols to
paralysed and non-paralysed ventilated rabbits. Amer J Respir Crit Care Med
1995;151:A746.
Chou KJ, Cunningham SJ, Crain EF.
Metered-dose inhalers with spacers vs nebulizers for pediatric asthma. Arch
Pediatr Adolesc Med 1995;149:201-5.
Nair LG, Diamond R, Falcone G, Thakore S,
Fine JM. Efficacy of mask spacer with metered dose inhaler in the frail elderly.
Chest 1995;108(Suppl):216S.
Chua HL, Chambers CB, Newhouse MT.
Comparison of MDI and MDI with four add-on devices on lung aerosol deposition
and function in asthmatics. J Aerosol Med 1995;8(P82):89.
〉程よ
Chua HL, Chambers CB, Newhouse MT. Upper
respiratory tract(URT) salbutamol (S) Deposition following MDI or MDI+
Aerochamber: Effect of mouth rinsing on oropharyngeal clearance. J Aerosol Med
1995;8(P83):89
Ahrens R, Lux C, Bahl T, Han S-H. Choosing
the metered-dose inhaler spacer or holding chamber that matches the patient's
need: Evidence that the specific drug being delivered is an important
consideration. J Allergy Clin Immunol 1995;96:288-94.
Shalansky KF, Htan EYH, Lyster DM, Mouat
B, Tweeddale MG. In vitro evaluation of the effect of metered-dose inhaler
administration technique on aerosolized drug delivery. Pharmacotherapy
1993;13:233-238.
Mitchell JP, Nagel MW, Newhouse MT.
Comparative performance of small volume plastic-and metal-bodied holding
chambers for pediatric use at low tidal volume. Eur Respir J 1996;9(Suppl
23):433S.
Albuterol delivery by metered-dose inhaler
in a mechanically ventilated pediatric Lung model~Crit Care Med -1996;
24:p870-874
Bronchodilator delivery with metered-dose
inhalers in mechanically-ventilated Patients~Eur Respir J 1996;9:p585-595
Effectiveness of Budesonide Aerosol in
Ventilator-Dependnt Preterm Babies A Preliminary Report~Pediatr Pulmonol
1996;21:p231-235
Efficiency of Aerosol Medication Delivery
From a Metered Dose Inhaler Versus Jet Nebulizer in infants With
Bronchopulmonary Dysplasia~Pediatr Pulmonol -1996;21:p301-309
TRIAL OF BECLOMETHASONE DIPROPIONATE BY
METERED-DOSE INHALER IN VENTILATOR-DEPENDENT NEONATES LESS THAN1500 GRAMS~Am J
of Perinatology-1996
Determinants of Aerosolized Albuterol
Delivery to Mechanically Ventilated Infants~CHHEST -1996;109(6):p1607-1613
Mitchell JP, Nagel MW. Comparison of
beclomethasone dipropionate(BDP) delivery using a large and small holding
chamber-in vitro measurements. Chest 1996;In Press.
Childers AG, Cummings RH, Kaufman BD,
Glennon JJ, Kelly EL, Lim JC, McNally C. Comparative study of dose delivery and
cascade impaction performance of four metered-dose inhaler and spacer
combinations. Curr Ther Research 1996;57:75-87
〉程よ
Clinical investigations Cardiovascular
Safety of High Doses of Inhaled Fenoterol and Albuterol in Acute Severe
Asthma~Chest -1996;110:p595-603
Rau JL, Restrepo RD, Deshpande V.
Inhalation of single vs multiple metered-dose bronchodilator actuations from
reservoir devices. An in vitro study. Chest 1996;109:969-74.
Campbell R, Nantel N, Tseng M, Newhouse M.
Larger lung targetable dose of albuterol from HFA MDI than CFC MDI:In vitro
measurements. Am J Respir Crit Care Med 1996;153:A63.
Tal A, Golan H, Grauer N, Aviram M, Albin
D, Quastel MR. Deposition pattern of radiolsbeled salbutamol inhaled from a
meterd-dose inhaler by means of a spacer with mask in young children with airway
obstruction . pediatr 1996;128:479-84.
Dhand R, Tobin MJ. Bronchodilator delivery
with metered-dose inhalers in mechanically-ventilated patients. Eur Respir J
1996;9:585-95.
Newhouse MT, Chapman KR, McCallum AL,
Abboud RT, Bowie DM, Hoder RV, Pare PD, Mesic-Fuch H, Molfino NA. Cardiovascular
safety of high doses of inhaled Fenoterol and Albuterol in acute severe asthma .
Newhouse MT er al. Chest 1996;110:595-603.
Giep T, Raibble P, Zuerlein T, Schwartz
ID. Trial of beclomethasone dipropinate by metered-dose inhaler in
ventilator-dependent neonates less than 1500 grams. Am J Perinatology
1996;13:5-9.
Lee H, Arnon S, Silverman M.
Bronchodilator aerosol administered by metered dose inhaler and spacer in
subacute neonatal respiratory distress syndrome. Arch Dis Child
1994;70:F218-F222.
Arnon S, Grigg J, Silverman M.
Effectiveness of budesonide aerosol in ventilator-dependent preterm babies: a
preliminary report. Pediatr Pulmonol 1996;21:231-235.
〉程よ
Gappa M, M. G,, rtner M, K"tting S, Poets
CF, von der Hardt H. Effectiveness of aslbutamol by MDI via spacer compared to
jet nebulizer on lung mechanics in very preterm infant with lung disease. Eur
Respir J 1996;9(Suppl 23):299S.
Bisgaard H, Berg E, Madsen J. Dose
delivery and fine particle dose of aerosol from three spacers intended for
asthma treament in young children. Eur Respir J 1996;9(Suppl 23):431S.
Barry PW, O'Callaghan C. The effect of
delay on the delivery of fluticasone and salmeterol from spacer devices. Eur
Respir J 1996;9(Suppl 23):432S.
Barry PW, O'Callaghan C. The effect of
breathing pattern on the clearnce of aerosol from spacers. Eur Respir J
1996;9(Suppl 23):432S.
Barry PW, O'Callaghan C. The effect of
breathing pattern on the output of budesonide from spacers. Eur Respir J
1996;9(Suppl 23):432S.
Mitchell JP, Nagel MW. Performance of a
140ml holding chamber with and without opportunity for ambient air ingress
during inhalation. Eur Respir J 1996;9(Suppl 23):433S.
Mitchell JP, Nagel NW, Dolovich MB.
Delivery of beclomethasone dipropionate(BDP) as a function of number of breaths
at low tidal volume in two small holding chambers for pediatric use. Eur Respir
J 1996;9(Suppl 23):433S.
Wildhaber JH, Devadason S, Eber E, Hayden
M, Summers QA, LeSou0/00f PN. Electrostatic charge, flow, delay and multiple
actuations influence the in vitro delivery of salbutamol from different small
volume spacers for infants. Eur Respir J 1996;9(Suppl 23): 433S.
Fuller HD, Dolovich M, Newhouse M. The
role of spacers in the treatment of mechanically ventilated patients receiving
bronchodilators. ISAM Focus Symposium: Aerosol Therapy with Small Volume
Nebulizers: Laboratory to Bedside. Tours, France. Sept 4-5, 1996.
Newhouse M, Brus RHP, Mahashabde S,
Chambers C, Choudhury S, Cooley S. In-vitro comparison of Azmacort_with integral
spacer (AZ) vs Aerobid_with Aerochamber_(AB-AC). ACCAI Annual Mtg. Nov 8-13,
1996. Boston, MA.
Mitchell JP, Nagel MW, Newhouse MT.
Performance of small volume plastic-and metal-bodied holding chambers for
pediatric use at low tidal volume. ACCAI Annual Mtg. Nov 8-13, 1996. Boston, MA.
Kanter LJ, Kanner RE. Drug delivery from a
metered dose inhaler(MDI) used with an inspiratory flow control device(IFCD),
compared to a space device(SD). AAAAI 52nd Annual Mtg. March 15-20, 1996. New
Orleans, LA.
Barry PW, O'Callaghan C. Inhalational drug
delivery from seven different spacer devices. Thorax 1996;51:835-840.
Vazquez Aceves ML, Gomez Castillo CA,
Martinez Cairo S, Cisneros Gonzalez N. Effect of FEV1 induced by the
adminstration of salbutamol with aerochamber and metered dose inhaler. [Spanish]
Revista Alergia Mexico 1995;42:41-4.
〉程よ
Bisgaard H, Anhoj J, Klug B, Berg E. A
non-electrostatic spacer for aerosol delivery. Arch Dis Child 1995;73:226-30.
Amirav I, Goren A, kravitz RM, Pawlowski
NA. Physician-targeted program on inhaled therapy for childhood asthma. J
Allergy Clin Immunol 1995;95:818-23.
Agertoft L, Pedersen S. influence of
spacer device on drug delivery to young children with asthma. Arch Dis Child
1994;71:217-9.
Arnon S, Grigg J, Nikander K, Silverman M.
Delivery of micronized budesonide suspension by metered dose inhaler and jet
nebulizer into a neonatal ventilator circuit. Pediatric Pulmonology
1992;13:172-5.
Joseph L Rau PhD RRT Ruben D Restrepo MD
RRT and Vijay Deshpande MS RRT Inhalation of Single vs Multiple Metered-dose
Bronchodilator Actuations From Reservoir Devices~Chest p1996;109-969-74
Williams JR, Bothner JP, Swanton RD.
Delivery of albuterol in a pediatric emergency department. Pediatr Emerg Care
1996;12:263-267.
Mahesh shrestha, MD; Khalil Bidadi, MD;
Scott Gourlay, RRT; and James Hayes, MD Continuous vs Intermittent Albuterol at
High and Low Doses in the Treatment of Severe Acute Asthma in Adults~Chest
1996;110:p42-47
Respiratory Care Standard Abbreviations
and Symbols~Respiratory Care-1997 VOL;42NO 6 p637-642
Iula Ak, Obetz CL, Deluccia FJ. Compartive
study of dose delivery from an Azmacort MDI paired with an Azmacort integrated
actuator/spacer, an Aerochamber, Inspirease and a Microspacer. Am J Respir Crit
Care Med 1997;155:A672.
In vitro comparison of the amount of
salbutamol available for inhalation from different formulations used with
different spacer devices~Eur Respir 1997;Jp1345-1348
Table1 Classification of severity of
asthma exacerbation -1997;NIH publication 97-4051
Coppolo D, Mitchell JP, Nagel NW.
Performance of the MV-Aerochamber holding chamber with CFC-and HFA-formulated
albuterol. Am J Respir Crit Care Med 1997;155:A770.
Nebuliser therapy in childhood~Tharax
-1997;52(supp1 2): s78-s88
Nebulisers for asthma~Tharax 1997;52(supp1
2):p s45-s48
Ildhaber JH, Hayden MJ, Dore ND, Devadason
SG, LeSouef PN. Salbutamol delivery from CFC free pMDI through a plastic spacer
in pediatric ventilator circuits. Am J Respir Crit Care Med 1997;155:A671.
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Inhaled Bronchidilator Therapy in
Mechanically Ventilated Patients~Am J Respir Crit Care Med pp3-10 -1997
Barry PW, O'Callaghan C. The output of
salbutamol from spacer devices. Am J Respir Crit Care Med 1997;155:A671.
Efficacy of Metered-Dose Inhaler
Administration of Albuterol in Intubated~CHEST -1997;112:p484-490
Devadason SG, Wildhaber JH, LeSouef PN.
The effect of static on the output from large and small spacers used with
HFA-inhalers. Am J Respir Crit Care Med 1997;155:A670
Wildhaber JH, Devadason SG, Eber E, Hayden
MJ, Everard ML, Summers QA, LeSou0/00f PN. Effect of electrostatic charge, flow,
delay and multiple actuations on the in vitro delivery of salbutamol from
different small volume spacers for infants. Thorax 1996;51:985-988.
Wandless JG. Use of the 'Aerochamber'
during induction of anaesthesia [letter]. Anaesthesia 1996;51:1193.
Raimondi AC, Schottlender J, Lombardi D,
Molfino NA. Treatment of acute severe asthma with inhaled albuterol delivered
via jet nebulizer, metered dose inhaler with spacer, or dry powder. Chest
1997;112:24-28.
Editor's Note:This compilation is adapted
from the recommendations of the American Physiological Society and the ACCP-ATS
Committee on Pulmonary Nomenclature Some additions have been made Respiratory
CARE -JUNE'97VOL42NO6
B.J. Lipworth & D.J.Clark Early lung
absorption profile of non-CFC salbutamol via small and large volume plastic
spacer devices~Br J Clin phormacol 1998; p45-48
Salbutamol Delivery From a
Hydrofluoroalkane Pressurized Metered-Dose Inhaler in Pediatric Ventilator
Circuits~CHEST -1998;113:p186-191
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Eleven peak flow meters a clinical
evaluation~Eur Respir J -1998 ;11:p188-193
Salbutamol Treatment of Acute Severe
Asthma in the ED MDI Versus Hand-Heid Nebulizer~Am J of Emerg-1998; 16: p637-342
Hemoptysis Due to MDI Therapy in a Patient
With Permsanent Tracheostomy~CHEST 1999;115: p279-282
P.W. Barry & C. O'Callaghan A comparative
analysis of the particle size output of beclomethasondiproprionate salmeterol
xinafoate and fluticasone propionate metered dose inhalers used with the
Babyhaler ~Blackwell Science Ltd 1999;47:357-360
Optimizing Deposition of Aerosolized Drug
in the Lung A Review~www.medscape.com.tw/viewarticle/408738 ~1999
MAREK ZAK M.D. JOOP MADSEN M.D. D.M.Sc.
and HANS BISGAARD M.D. D.M.Sc A Mathematical Model of Aerosol Holding
Chambers~Journal of Aerosol Medicine 1999 Mary ; p187-196
AARC Clinical Practice Guideline Selection
of Device Administration of Bronchodilator and Evaluation of Response to Therapy
in Mechanically Ventilated Patients~Respir Care-1999;44(1):p105-113
Reconciling In Vitro and In Vivo
Measurements of Aerosol Delivery from aMetered-Dose Inhaler during Mechanical
Venttilation and Defining Efficiency-enhancing Factors~Am J Respir Crit Care Med
Vol -1999;159:p63-68
Hemoptysis Due to MDI therapy in a patient
with permanent tracheostomy19991る
Evaluating the Delivery of Nebulized-Dose
Inhalers in an In Vitro Infant Ventilator Lung Model~Ann Pharmacother
-1999;33:p144-148
A Comparison of Bronchodilator Therapy
Delivered by Nebulization and Metered-Dose Inhaler in Mechanically Ventilated
Patients ~CHEST -1999;115 :p1653-1657
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Inhalation therapy in asthma Nebulizer or
pressurized metered-dose inhaler with holding chamber in vivo comparison of lung
deposition in children 1999:p28~33
AeroChamber Plus VHC Gossary -1999
Leonard Bielory Frank Picone Paul
Rabinowitz Leonard Rossoff John Winder Gary Incaudo Jane Wu and Kenneth Newman
Multicentre Randomised Parallel-Group Study of the Efficacy and Tolerability of
Flunisolide - Administered Once Daily via AeroChamber in the Treatment of Mild
to Moderate Asthma Clin Drug Invest 2000Fed;19(2):93-101
Comparison of efficacy and safety between
flunisolide AeroChamber and budesonide turbuhaler in patients with moderate
asthma~Ann Allergy Asthma Immunol 2000;84:p313-319
Costs and effectiveness of spacer versus
nebulizer in young children with moderate and severe acute asthma~J Pediatr
-2000;136:p497-502
Kutay Demirkan PharmD Elizabeth Tollye
Mastin RN BSN Judith Soberman MD Joy Burbeck MD and Timothy Self PharmD.
Salmeterol Administration by Metered-Dose Inhaler Alone vs Metered-Dose Inhaler
Plus Valved Holding Chamber - CHEST 2000; 117:1314-1318
Variability in lung deposition inhaled
drug,within and between asthatic patients,with a pMDIand dry powder
inhaler,turbuhaler~International Journal of
Pharmaceutics-1999;193(2000):p227-230
Nebulizers Principles and
Performance~Respiratory Care 2000;45(6): p609-622
Leonard Bielory Frank Picone Paul
Rabinowitz Leonard Rossoff John Winder Gary Incaudo Jane Wu and Kenneth Newman
Multicentre Randomised Parallel-Group Study of the efficacy and Tolerability of
Flunisolide Administered Once Daily via AeroChamber in the treatment of Mild to
Moderate Asthma 2000Fed:19 (2):93-101
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Salmeterol Administration by metered Dose
Inhaler Alone vs Metered-Dose Inhaler Plus Valved Holding Chamber ~Chest
-2000May;117:91314-1318
H J Zar, E G Weinberg, H J Binns, F Gallie
M D Mann Lung deposition of aerosol-a comparison of different spacers~Arch Dis
Child 2000;82:495-498
Consensus Statement Aerosols and Delivery
Devices~Respiratory Care -2000;45(6): p589-596
Aerosol Device Selection Evidence to
Practice~Respiratory Care -2000;45(7):p874-885
Water accumulation in metered dose inhaler
spacers under normal mechanical ventilation conditions~Heart&Lung
2000;29:424-428.
Inhaled Fraction~Article received DIOT ET
AL. 2000;p58-64
Budesonide Inhalation Suspension A Review
of its Use in Infants Children and Adults with Inflammatory Respiratory
Disorders~Drugs2000 11;60
Successful implementation of spacer
treatment guideline for acute asthma2001;84:p142-146
FEV1 Useful in Assessing Airway
Responsiveness in Asthmatic Children~Chest 2001;120:1843-1849
Oxygen Should Be First Treatment Given to
Patients With Severe Asthma~BMJ 2001;323:p98-100
C V E Powell, G R Maskell, M K Marks, M
South, C F Robertson. Successful implementation of spacer treatment guideline
for acute asthma~Arch Dis Child -2001;84:p142-146
ARIEL BERLINSKI M.D. and J. CLIFFORD
WALDREP Ph.D. Metering Performance of Several Metered-Dose Inhalers with
Different Spacers Holding Chambers~Journal of Aerosol Medicine 2001
Mary;p427-432 -
The Equivalence of Compressor
Pressure-Flow Relationships with Respect to Jet Nebulizer Aerosolization
Characteristics~Journal of Aerosol Medicine -2001p31-42
E Dompeling A M Oudesluys-Murphy h m
Janssens H M Janssens W Hop J G Brinkman R N Sukhai J C de Jongste Randomised
controlled study of clinical efficacy of spacer therapy in asthma with regard to
electrostatic charge~Arch Dis Child 2001;84:p178-182
JACKIE RICHARDS PhD PETER HIRST PhD GARY
PITCAIRN PhD SHASHANK MAHASHABDE PhD WATTANAPORN ABRAMOWITZ PhD ARNO NOLTING PhD
and STEPHEN P NEWMAN PhD Deposition and Pharmacokinetcs of Flunisolide Delivered
from Pressurized Inhalers Containing Non-CFC Propellants -JOURNAL OF AEROSOL
MEDICINE -2001Mary;p197-208
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Component1~Gpldcopd exec summary 2001
Component3 Manage Siable COPD~Goldcopd
exec summary 2001
Component4 Manage Exacerbations ~Goldcopd
exec summary 2001
N. M. Eiser C. Phillips AND P. A. WOOLER
Does the mode of inhalation affect the bronchodilator response in patients with
severe COPD~Restpiratory Medicine -(2001)95, p476-483
Aerosol Therapy With Valved Holding
Chambers in Young Children Importance of the
Facemaskseal~Pediatrics-2001;p389~394
Management of Acute Exacerbations of
Chronic Obstructive Pulmonary Disease~Pharmacotherapy 2001;21(8)p929-939
Effective Dose of Salmeterol Can Be
Administered With Valved Holding Chamber~Ann Allergy Asthma Immunol -Ann Allergy
Asthma Immunol 2001;87:482-487
Israel Amirav MD and Michael T Newhouse MD
MSc FRCP(C) FACP FCCP Aerosol Therapy With Valved Holding Chambers in Young
Children Importance of the Facemask Seal -PEDIATRICS Vol.108 NO 2 AUGUST 2001
Michael J. Asmus PharmD Judy Liang PharmD
Intira Coowanitwong MS Ramin Vafadari and Guenther Hochhaus PhD In vitro
deposition of fluticasone aerosol from ametered inhaler with and without two
common valved holding chambers~Ann Allergy Asthma Immunol 2002;88:152-161
Global strategt for asthmama management
and prevention -2002
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Optimizing Deposition of Aerosolized Drug
in the Lung A Review -2002
Fluticasone Inhaler Use May Cause
Laryngitis~Ach Otolaryngol Head Neck Surg -2002;128:p677-681
Asmus MJ Liang J,Coowanitwong I, Vafadari
R,Hochhaus G. In vitro deposition of Fluticasone aerosol from a metered-dose
inhaler with and without two common valved holding chambers~Ann Allergy Asthma
Immunol -2002 Fed;88(2):p204-208
Performance of large-and small-volume
valved holding chambers with a new combination long-term bronchodilator
anti-inflammatory formulation delivered by pressurized metered dose inhaler~J
Aerosol 2002Med ;15(4):427-33
Nebulizers vs Metered-Dose Inhalers With
Spacers for Bronchodilator Therapy to Treat Wheezing in Children Aged 2 to 24
Months in a Ped0iatric Emergency Department 2003;157:p76-80
An in vitro investigation of common
nebulizer dosing protocols comparing a breath-actuated with conventional
pneumatic small volume nebulizer~Respiratory Drug Delivery 2003;48(1):p46-51
Current Concepts in Pharmacologic
Management of Chronic Obstructive Pulmonary Disease~www.medscape.com viewarticie
417589 www.medscape.com -2003
Inhaled glucocorticoids versus leukotriene
receptor antagonists as single agent asthma treatment systematic review of
current evidence -2003;326:p621-3
Effect of montelukast added to inhaled
budesonide on control of mild to moderate asthma~Tharax -2003;58:p204-211
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Effect of the Addition of Montelukast to
Inhaled Fluticasone Propionate on Airway Inflammation~Am J Respir Crit Care Med
-2003;167:p745-750
Lung Deposition and Respirable Mass During
Wet Nebulization~Journal Of Aerosol Medicine -2003;pp379-386
Albuterol Aerosol Delivered vie
Metered-Dose Inhaler to Intubated Pediatric Models of 3Ages With 4Spacer
Designs~Respiratory Carep-2003;948-955
The Delivery of
ChloroFluorocarbon-Propelled Versus Hydrofluoroalkane-Propelled Patient A
Laboratiory Study~Respiratory Care 2003;pp1025-1032
Safety of inhaled corticosteroids
delivered by plastic and metal spacers~Arch Dis Child 2003527~528
Accuracy of Float Testing for Metered-Dose
Inhaler Canisters ~www.medscape.com viewarticle 449883 print -2003
Use of the AeroChamber Brand of Valved
Holding Chamber in the ER~Printed in Canada MD-2003;157:76-80.
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The Delivery of
ChloroFluorocarbon-Propelled Versus Hydrofluoroalkane-Propelled Patient A
Laboratiory Study~Respiratory Care -2003;pp1025-1032
Comparison of Breath-actuated and
Conventional Constant-Flow Jet Nebulizers in Treating Acute Asthmatic
Children~Acta PaediatrTw 2004 ;45: 73-6
Performance Comparison of Nebulizer Design
Constant-output Breath-Enhanced and Dosimetric2004;49(2):p174-179.
˙币笆籔尿瑈蔼溃砰铭て竟ノ獀励齿眞担ぇゑ耕~狶莱礛20044る
The influence of formulation and spacer
device in vitro performance of solution chorofluorocarbon-free propellant-driven
metered dose inhalers~Controlled Clinical Trials 2004;pp286-310
2004The Inhalation of Drugs Advantages and
Problems~ Respir Care 2005;50(3):p367-382.
2004 Philip Kittredge Memorial Lecture The
Inhalation of Drugs Advantages and Problems -Respir Care 2005-50-3-p367-382
芖洛厩Formosan Journal of Medicine
2005;9:18-28.
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